Repository logo

Browsing by Subject "bone tissue engineering"

Filter results by typing the first few letters
Now showing 1 - 4 of 4
  • thumbnail.journal.alt
    Item type:Thesis, Access status: Restricted ,
    Composite biomaterials for tissue regeneration
    (Data obrony: 2018-07-04) Kocot, Magdalena
    Wydział Elektrotechniki, Automatyki, Informatyki i Inżynierii Biomedycznej
  • thumbnail.journal.alt
    Item type:Thesis, Access status: Restricted ,
  • thumbnail.journal.alt
    Item type:Article, Access status: Open Access ,
    Poly(L-lactide)/nano-hydroxyapatite piezoelectric scaffolds for tissue engineering
    (2025) Zaszczyńska, Angelika; Gradys, Arkadiusz; Kołbuk, Dorota; Zabielski, Konrad; Szewczyk, Piotr K.; Stachewicz, Urszula; Sajkiewicz, Paweł
    Wydział Inżynierii Metali i Informatyki Przemysłowej
    The development of bone tissue engineering, a field with significant potential, requires a biomaterial with high bioactivity. The aim of this manuscript was to fabricate a nanofibrous poly(L-lactide) (PLLA) scaffold containing nano-hydroxyapatite (nHA) to investigate PLLA/nHA composites, particularly the effect of fiber arrangement and the addition of nHA on the piezoelectric phases and piezoelectricity of PLLA samples. In this study, we evaluated the effect of nHA particles on a PLLA-based electrospun scaffold with random and aligned fiber orientations. The addition of nHA increased the surface free energy of PLLA/nHA (42.9 mN/m) compared to PLLA (33.1 mN/m) in the case of aligned fibers. WAXS results indicated that at room temperature, all the fibers are in an amorphous state indicated by a lack of diffraction peaks and amorphous halo. DSC analysis showed that all samples located in the amorphous/disordered alpha' phase crystallize intensively at temperatures just above the Tg and recrystallize on further heating, achieving significantly higher crystallinity for pure PLLA than for doped nHA, 70 % vs 40 %, respectively. Additionally, PLLA/nHA fibers show a lower heat capacity for PLLA in the amorphous state, indicating that nHA reduces the molecular mobility of PLLA. Moreover, piezoelectric constant d33 was found to increase with the addition of nHA and for the aligned orientation of the fibers. In vitro tests confirmed that the addition of nHA and the aligned orientation of nanofibers increased osteoblast proliferation.
  • thumbnail.journal.alt
    Item type:Thesis, Access status: Restricted ,
    Skafoldy nanokompozytowe do leczenia ubytków tkanki kostnej
    (Data obrony: 2012-01-26) Miranowicz, Magdalena
    Międzywydziałowa Szkoła Inżynierii Biomedycznej