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Browsing by Subject "cellular clearance"

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  • thumbnail.journal.alt
    Item type:Article, Access status: Open Access ,
    Analiza wrażliwościowa wyznaczanego optymalizacyjnie klirensu komórkowego w modelu dwuprzedziałowym
    (Wydawnictwa AGH, 2006) Korohoda, Przemysław
    The paper considers the kinetic urea modelling, a tool used in the haemodialysis treatment. The efforts to introduce the two-compartmental model to the practical applications are mitigated by the lack of numerical value for the cellular clearance, Kc, being the crucial parameter of this model. The optimisation procedure, utilising the adjusted model technique to assess the Kc value, should be applied with the knowledge about relevant sensitivity of the resulting values to the changes in the input parameters. The changes that result from the inevitable measurement errors. In the paper a method of evaluating the required sensitivity values is described and a computational example based on the typical values is provided. The obtained results may be used to indicate the input parameters which must be measured with particular care. Application of the described procedure should provide arguments to recognise if the differences between the obtained Kc values result from inaccuracy of the input values or indicate the important phenomena.
  • thumbnail.journal.alt
    Item type:Article, Access status: Open Access ,
    Modelowanie hemodializy na podstawie danych pomiarowych - procedura optymalizacyjna dla modelu dwuprzedziałowego
    (Wydawnictwa AGH, 2007) Korohoda, Przemysław
    In the paper a multistage optimization procedure has been proposed. The technique had been designed to make possible the computation of the cellular clearance based only on the data measured during hemodialysis treatment. The iterative structure of the proposed algorithm allows subtle corrections on the values of the urea generation and recirculation. The description has been illustrated with some resulting examples and also with the summary data. The technique proved to be convergent for measurements performed during 91 dialysis sessions, while introducing the relative error into modelled external compartment urea concentration with the mean value 0.51% and standard deviation 2.80%.