Browsing by Subject "chitosan"

Now showing 1 - 6 of 6

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Badanie hydrożeli na bazie chitozanu i cząstek ceramicznych
(Data obrony: 2018-11-16) Kukułka, Aneta
Wydział Elektrotechniki, Automatyki, Informatyki i Inżynierii Biomedycznej
Access status: Open Access ,
Improving stability and mechanical strength of electrospun chitosan-polycaprolactone scaffolds using genipin cross-linking for biomedical applications
(2025) Uma Thanu Krishnan Neela, Nagalekshmi; Szewczyk, Piotr K.; Karbowniczek, Joanna; Polak, Martyna; Knapczyk-Korczak, Joanna; Stachewicz, Urszula
WIMiIP
Electrospun nanofiber scaffolds have become vital in biomedical applications due to their high surface area and tunable properties. Chitosan (CS) is widely used, but its rapid degradation limits its effectiveness. This study addresses this limitation by blending CS with polycaprolactone (PCL) and applying genipin cross-linking to enhance its stability and mechanical properties. Scanning electron microscopy indicated a uniform morphology of the electrospun fibers, and further, the crystallinity of the scaffolds before and after cross-linking is verified. Fourier-transform infrared spectroscopy is used to analyze the chemical structure, identifying the presence of trifluoroacetic acid residues in the as-spun fibers. These residues are successfully eliminated through neutralization and cross-linking, which are critical for enhancing stability and cell viability in in-vitro studies. Mechanical testing revealed that cross-linked CS+PCL scaffolds exhibit a 350% increase in tensile strength compared to pure CS, and zeta potential reaches the favorable for cell development -26.27 mV. The cytotoxicity assay results with murine NIH 3T3 fibroblast cells indicate the suitability of CS+PCL scaffolds for targeted tissue engineering and wound healing. This work establishes the potential for fine-tuning scaffold properties to create stable, functional, and biocompatible substrates for extended biomedical use.
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Kompozyty chitozan/tlenek grafenu do zastosowań w inżynierii tkanki chrzęstnej
(Data obrony: 2018-09-24) Wesołowska, Paula
Wydział Elektrotechniki, Automatyki, Informatyki i Inżynierii Biomedycznej
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Modyfikowane hydrożele na bazie polimerów naturalnych - otrzymywanie i charakterystyka
(Data obrony: 2020-07-15) Sądej, Michalina
Wydział Inżynierii Materiałowej i Ceramiki
Access status: Open Access ,
Strength, water absorption, thermal and antimicrobial properties of a biopolymer composite wound dressing
(AGH University of Science and Technology Press, 2022) Chiosa Odili, Cletus; Sekunowo, Olatunde Israel; Ilomuanya, Margaret Okonawan; Gbenebor, Oluwashina Philips; Adeosun, Samson Oluropo
Conventional wound material allows bacterial invasions, trauma and discomfort associated with the changing of the dressing material, and the accumulation of body fluid for wounds with high exudate. However, there is a shift from conventional wound dressing materials to polymeric nanofibers due to their high surface area to volume ratio, high porosity, good pore size distribution, which allows for cell adhesion and proliferation. There is an urgent need to synthesis a biodegradable composite that is resistant to bacterial infection. In this study, an electrospun polylactide (PLA) composite suitable for wound dressing, with enhanced antimicrobial and mechanical properties, was produced. The neat PLA, PLA/CH (10 wt.%), PLA/CH (5 wt.%), PLA/CHS (10 wt.%), PLA/CHS (5 wt.%), PLA/CH (2.5 wt.%) /CHS (2.5 wt.%) and PLA/CH (5 wt.%)/CHS (5 wt.%), were electrospun using 0.14 g/ml solution. Results show that crystallinity (67.6%) of neat PLA declined by 3.8% on the addition of 2.5 wt.% chitin/chitosan with improved hydrophilicity of the composite. The tensile strength of neat PLA (0.3 MPa) increased (0.6 MPa) with 2.5 wt.% chitin/chitosan addition. The slight increase in the glass transition temperature from 75°C for neat PLA to 78°C of the composite fibre, showed improved ductility. The fibres showed little beads, hence suitable for wound dressing. The electrospun mats have good water absorption capacity and strong resistance against <i>Staphylococcus aureus</i>. Good performance was attained at 5 wt.% of chitin, chitosan and hybrid reinforcements. Therefore, a PLA/chitin/chitosan composite is recommended as a wound dressing material.
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Wpływ obecności minerałów ilastych na degradację wybranych polimerów biodegradowalnych
(Data obrony: 2017-01-25) Kozień, Dawid
Wydział Geologii, Geofizyki i Ochrony Środowiska
Celem poniższej pracy inżynierskiej była synteza biodegradowalnych biopolimerów interkalowanych zmodyfikowanymi minerałami ilastymi. Synteza cienkich folii chitozanu wymaga interkalacji minerałów ilastych: wemikulitu, montmorillonitu i laponitu. Modyfikacja minerałów ilastych polegała na interkalacji bromkiem heksadecylotrimetyloaniowym (HDTMA). Metody wykorzystane do badania to dyfraktometria rentgenowska (XRD) i spektroskopia absorpcyjna w podczerwieni (FT-IR). Synteza cienkich folii biopolimerów biodegradowalnych chitozanu minerałami ilastymi jest możliwa metodą rozpuszczalnikową. Tempo biodegradacji bipolimerów cienkich folii na bazie chitozanu jest zależna od rodzaju minerału ilastego w strukturze chitozanu.