Zima, Aneta
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inżynieria biomedyczna
inżynieria materiałowa
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Item type:Presentation, Access status: Open Access , Calcium phosphate-based hybrid biomaterials for bone regeneration and local antibacterial therapyPańtak, Piotr; Belcarz, Anna; Czechowska, Joanna P.; Zima, Aneta
Wydział Inżynierii Materiałowej i CeramikiComposites based on hydroxyapatite (HA) and/or tricalcium phosphate (TCP) along with polymers, are widely used in bone regeneration due to their excellent biocompatibility. However, one of the challenges associated with their implantation procedures is the occurrence of inter- and post-operative bacterial infections. To address this issue biomaterials can be enriched with antibacterial agents such as: metallic nanoparticles (eg. AgNPs, AuNPs), ions (Cu2+, Ag+) or antibiotics, which can effectively inhibit the growth and proliferation of a wide range of bacteria. In this study, composites based on αTCP and hybrid granules were developed and examined. Hybrid granules composed of hydroxyapatite, methylcellulose and/or chitosan were obtained via wet-chemical method. Materials were enriched with various nanoparticles, including AuNPs, AgNPs and CuONPs. The chemical and phase composition (XRF,XRD), setting times (Gillmore Apparatus), and compressive strength (Instron 3345) were examined. Microstructure was observed using SEM. Furthermore, the bioactive potential in vitro in SBF as well as antibacterial activity against E. coli, and S. aureus were evaluated. In the present study, some key features were improved by developing novel biomaterials. The designed composites offer biocompatibility, sufficient mechanical and antibacterial properties. Based on the obtained results, it can be concluded that the developed materials hold promise as candidates preventing post-surgical infections in hard tissue applications. Further biological studies are necessary to comprehensively characterize these biomaterials. Acknowledgments Research project supported by the programme ‘Excellence initiative – research university” for the AGH University of Science and Technology and the AGH Faculty of Materials Science and Ceramics (Project No. 16.16.160.557). This research was funded in whole or in part by National Science Centre, Poland (Project MINIATURA7 No. 2023/07/X/ST11/00705). For the purpose of Open Access, the author has applied a CC-BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission.Item type:Article, Access status: Open Access , Hybrid bone substitute containing tricalcium phosphate and silver modified hydroxyapatite–methylcellulose granules(2024) Czechowska, Joanna P.; Dorner-Reisel, Annett; Zima, Aneta
Wydział Inżynierii Materiałowej i CeramikiDespite years of extensive research, achieving the optimal properties for calcium phosphate-based biomaterials remains an ongoing challenge. Recently, ‘biomicroconcretes’ systems consisting of setting-phase-forming bone cement matrix and aggregates (granules/microspheres) have been developed and studied. However, further investigations are necessary to clarify the complex interplay between the synthesis, structure, and properties of these materials. This article focusses on the development and potential applications of hybrid biomaterials based on alpha-tricalcium phosphate (αTCP), hydroxyapatite (HA) and methylcellulose (MC) modified with silver (0.1 wt.% or 1.0 wt.%). The study presents the synthesis and characterization of silver-modified hybrid granules and seeks to determine the possibility and efficiency of incorporating these hybrid granules into αTCP-based biomicroconcretes. The αTCP and hydroxyapatite provide structural integrity and osteoconductivity, the presence of silver imparts antimicrobial properties, and MC allows for the self-assembling of granules. This combination creates an ideal environment for bone regeneration, while it potentially may prevent bacterial colonization and infection. The material’s chemical and phase composition, setting times, compressive strength, microstructure, chemical stability, and bioactive potential in simulated body fluid are systematically investigated. The results of the setting time measurements showed that both the size and the composition of granules (especially the hybrid nature) have an impact on the setting process of biomicroconcretes. The addition of silver resulted in prolonged setting times compared to the unmodified materials. Developed biomicroconcretes, despite exhibiting lower compressive strength compared to traditional calcium phosphate cements, fall within the range of human cancellous bone and demonstrate chemical stability and bioactive potential, indicating their suitability for bone substitution and regeneration. Further in vitro studies and in vivo assessments are needed to check the potential of these biomaterials in clinical applications.Item type:Presentation, Access status: Open Access , Self-assembling, antibacterial hybrid calcium phosphate-based compositesCzechowska, Joanna P.; Pańtak, Piotr; Belcarz, Anna; Kowalska, Kinga J.; Zima, Aneta
Wydział Inżynierii Materiałowej i CeramikiSelf-assembling materials have emerged as a groundbreaking solution in tissue engineering, offering innovative strategies to combat bacterial infections. Special attention is given to the hybrid granules. Our research focuses on self-assembling, antibacterial hybrid granules composed of hydroxyapatite, methylcellulose, and/or chitosan. These granules were produced via modified wet-chemical method and enriched with ions or nanoparticles (Cu 2+ , CuONPs). The chemical and phase compositions (XRF, XRD, FT-IR, Raman), compressive strength, thermal properties and microstructure were analyzed. Additionally, their bioactivity in simulated body fluid and antibacterial effectiveness against E. coli and S. aureus were tested. The obtained results are particularly promising as hybrids showed high mechanical strength, biocompatibility and antibacterial properties. Granules may be applied independently or as components of innovative biocomposites. Supported by the programme “Excellence initiative – research university” for the AGH University of Science and Technology and the AGH Faculty of Materials Science and Ceramics (No. 16.16.160.557). This research was funded in whole or in part by National Science Centre, Poland (Project MINIATURA7 No. 2023/07/X/ST11/00705). For the purpose of Open Access, the author has applied a CC-BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission.Item type:Doctoral Dissertation, Access status: Open Access , Wpływ dodatków modyfikujących na właściwości hydroksyapatytowych wielofunkcyjnych tworzyw implantacyjnych przeznaczonych na nośniki leków(Data obrony: 2007) Zima, Aneta
Wydział Inżynierii Materiałowej i CeramikiImplant materials which can be used as drug carriers have to meet many strict requirements such as appropriate open and total porosity, size and shape of pores and also adequate mechanical strength. It is recommended that open pore system enables slowly release of medium incorporated into drug delivery system. The rate and quantity of released medicament depend mainly from physical properties of biomaterial (particularly its microstructure), the medicament replacement in the implant volume (home- and heterogeneous system), also from the type of drug and its physicochemical properties. The aim of this work was to elaborate modified multifunctional bioceramics hydroxyapatite implants for bone defect filling and local drug delivery system (DDS), that will be placed in not loaded body parts. The kinetic of drug released in homo- and heterogeneous system was evaluated. For modification of Hap bioceramic $Ca(PO_{3})_{2}$ and $Mg_{3}(PO_{4})_{2} 8H_{2}O$ were used.Item type:Article, Access status: Open Access , The influence of titanium and cooper on physiochemical and antibacterial properties of bioceramic-based composites for orthopaedic applications(2025) Pańtak, Piotr; Belcarz, Anna; Czechowska, Joanna P.; Zima, Aneta
Wydział Inżynierii Materiałowej i CeramikiThis study examines the impact of titanium and copper ion modifications on the properties of hybrid hydroxyapatite/chitosan granules, which serve as components of novel injectable bone substitutes - biomicroconcretes. In addition to the hybrid granules, the powdered phase of the composites comprises highly reactive α-tricalcium phosphate (α-TCP) powder. The utilization of a mixture consisting of citrus pectin and disodium phosphate as the liquid phase of bone substitutes facilitated the development of easily mouldable, fully injectable biomicroconcretes based on calcium phosphate, characterized by distinct properties. The resulting biomicroconcretes demonstrated favourable cohesion and setting times falling within acceptable parameters. Furthermore, the incorporation of citrus pectin into the liquid phase significantly augmented the mechanical strength of the materials. The unique attributes of biomicroconcretes containing citrus pectin arise from the presence of both a dual setting system and a double hybrid system. The dual setting mechanism, stemming from the hydrolysis of α-TCP and the crosslinking of citrus pectin in the presence of Ca2⁺ ions, yielded materials distinguished by excellent cohesion and chemical stability. Conversely, the double hybrid system emerged from the coexistence of hybrid granules and interactions between polycationic chitosan within the hybrid granules and polyanionic citrus pectin. All obtained biomicroconcretes exhibited in vitro bioactivity, positioning them as promising candidates for further biological investigations. Notably, the integration of antibacterial copper ions into hybrid hydroxyapatite/chitosan granules significantly enhances their potential utility as bone substitute materials, effectively reducing the risk of S. aureus and E. coli infection during surgical procedures. It has been found that titanium modified composites reduced adhesion of S. aureus but did not reduce the adhesion of E. coli cells. This research validates the advantageous properties of the synthesized ceramic-based biomaterials and sets the stage for subsequent in vitro and in vivo studies.